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Wii "S" Games
- Samba De Amigo
- Samurai Slash
- Samurai Warriors: Katana
- Scarface: The World Is Yours
- Sega Bass Fishing
- Sega Superstars Tennis
- Showtime Championship Boxing
- Shrek Smash 'n' Crash
- Shrek the Third
- Sid Meier's Civilization Revolution
- The Simpsons Game
- The Sims 2: Castaway
- The Sims 2: Pets
- Smarty Pants
- Solitaire & Mahjong
- Sonic and the Secret Rings
- Sonic Riders: Zero Gravity
- Sonic Unleashed
- Soul Calibur Legends
- Space Chimps
- Space Station Tycoon
- Speed Racer: The Videogame
- Spider-Man: Friend or Foe
- Spider-Man: Web of Shadows
- Spiderman 3
- Spiderwick Chronicles
- SpongeBob SquarePants featuring Nicktoons: Globs of Doom
- SpongeBob SquarePants: Creature from the Krusty Krab
- SpongeBob's Atlantis SquarePantis
- Spy Fox in Dry Cereal
- Spy Games: Elevator Mission
- Spyro: Dawn of the Dragon
- SSX Blur
- Star Trek: Conquest
- Star Wars: The Force Unleashed
- Summer Athletics
- Summer Sports: Paradise Island
- Super Mario Galaxy
- Super Monkey Ball: Banana Blitz
- Super Paper Mario
- Super Smash Bros. Brawl
- Super Swing Golf
- Super Swing Golf: Season 2
- Surf's Up